Search results for "chiral [perturbation theory]"
showing 10 items of 412 documents
Iminium Catalysis (n → π*)
2016
A P-chirogenic β-aminophosphine synthesis by diastereoselective reaction of the α-metallated PAMP–borane complex with benzaldimine
2004
International audience; The diastereoselective synthesis of a P-chirogenic β-aminophosphine ligand with carbon–carbon bond formation of the ethano bridge in a 3:1 ratio via reaction of an α-metallated P-chirogenic phosphine borane with a benzaldimine is described. The diastereoselectivity is attributed to a transition state where the lithium cation chelates the phosphine borane carbanion and the nitrogen of the imine and the attack of the C@N occurs on the face opposite to the P–B bond, due to its interaction with the antibonding P–B bond. The major diastereoisomeric β-aminophosphine borane was then separated and decomplexed into the corresponding β-aminophosphine under neutral conditions a…
Diastereoselective synthesis of 6-functionalized 4-aryl-1,3-oxazinan-2-ones and their application in the synthesis of 3-aryl-1,3-aminoalcohols and 6-…
2010
Abstract Halocyclocarbamation of benzyl N -(1-phenyl-3-butenyl)carbamates afforded 6-functionalized 4-aryl-1,3-oxazinan-2-ones with moderate to excellent diastereoselectivity depending on the N -substituent. Importantly, in contrast to reported cyclocarbamations of homoallylic carbamates, which are generally trans -diastereoselective, cyclization of N -unsubstituted Cbz-protected homoallylamines led to cis -1,3-oxazinan-2-ones, predominantly. The use of N -benzylated and in situ prepared N -silylated derivatives resulted however in trans -selectivity. Transition states are proposed to explain the stereochemical influence of the N -substituent on the cyclocarbamations. The functionalized 1,3…
Investigation of molecular states with charm and beauty hadrons
2014
La Fisica de hadrones ha tenido un desarrollo espectacular en los ultimos años debido a la pletora de estados nuevos que han sido descubiertos en laboratorios como BES en Beijing, la colaboracion Babar en USA, Belle en Japon, CLEO en USA y el CERN en Europa, entre otros. El modelo de quarks, segun el cual los mesones estan formados de quark antiquark y los bariones de tres quarks, tuvo en su dia un valor incalculable, al permitir entender los hadrones en terminos de unos pocos componentes elementales. Las predicciones que hizo, y fueron confirmadas, puso este modelo de los hadrones en un lugar incuestionable de la Historia de la Fisica. Sin embargo, el paso del tiempo nos ha ido enseñando q…
Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling…
2005
The enantiomeric resolution of chiral compounds using HSA by means of affinity EKC (AEKC)-partial filling technique is the result of a delicate balance between different experimental variables such as protein concentration, running pH (background electrophoretic buffer, protein and compound solutions) and protein solution plug length. In this paper multivariate optimization approaches for chiral separation of four basic drugs (alprenolol, oxprenolol, promethazine and propranolol) using HSA as chiral selector in AEKC-partial filling technique are studied. The experimental conditions to achieve maximum resolution are optimized using the Box-Behnken experimental design. Partial least squares a…
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
2022
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity. This research was funded by the National Na…
On-surface Synthesis of a Chiral Graphene Nanoribbon with Mixed Edge Structure.
2020
Abstract Chiral graphene nanoribbons represent an important class of graphene nanomaterials with varying combinations of armchair and zigzag edges conferring them unique structure‐dependent electronic properties. Here, we describe the on‐surface synthesis of an unprecedented cove‐edge chiral GNR with a benzo‐fused backbone on a Au(111) surface using 2,6‐dibromo‐1,5‐diphenylnaphthalene as precursor. The initial precursor self‐assembly and the formation of the chiral GNRs upon annealing are revealed, along with a relatively small electronic bandgap of approximately 1.6 eV, by scanning tunnelling microscopy and spectroscopy.
The role of the $\Delta(1232)$-resonance in covariant baryon chiral perturbation theory
2013
We stress, on theoretical and phenomenological grounds, the importance of the $\Delta(1232)$-resonance in a chiral effective field theory approach applied to the study of $\pi N$ scattering. We show how its inclusion as a dynamical degree of freedom allow us to obtain reliably valuable information from $\pi N$ scattering data.
Pion photo- and electro-production and the chiral MAID interface
2016
We discuss the extended on-mass-shell scheme for manifestly Lorentz-invariant baryon chiral perturbation theory. We present a calculation of pion photo- and electroproduction up to and including order q 4 . The low-energy constants have been fixed by fitting experimental data in all available reaction channels. Our results can be accessed via a web interface, the so-called chiral MAID (http://www.kph.uni-mainz.de/MAID/chiralmaid/). We explain how our program works and how it can be used for further analysis.
Including theΔ(1232)resonance in baryon chiral perturbation theory
2005
Baryon chiral perturbation theory with explicit $\ensuremath{\Delta}(1232)$ degrees of freedom is considered. The most general interactions of pions, nucleons, and \ensuremath{\Delta} consistent with all underlying symmetries as well as with the constraint structure of higher-spin fields are constructed. By use of the extended on-mass-shell renormalization scheme, a manifestly Lorentz-invariant effective-field theory with a systematic power counting is obtained. As applications, we discuss the mass of the nucleon, the pion-nucleon \ensuremath{\sigma} term, and the pole of the \ensuremath{\Delta} propagator.